We describe a patient with overlap syndrome in whom systemic lupus erythematosus and scleroderma were combined. The patient expired due to severe central nervous nervous system involvement and pneumonia. Pertinent neuropsychiatric signs of the
patient
included generalized seizure, impairment of recent memory, dysarthria, mental deterioration, Balint's syndrome, right sided hemiparesis and right sided central type facial weakness. Brain MRI and cerebral angiogram showed cerebral vasculopathy.
We
suggest that a long-term follow-up is necessary for the confirmation of diagnosis of a commective tissue disease, because the evolution, transition and overlapping features among the group of connective tissue diseases may commonly occur over
time.
(Kor
J Dermatol 1994 ; 32(2) : 347~351)
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